Volume 46, Issue 6, November 2020, Page 693-707.

We reconstruct recent work on macrosocial stress as if it were an instance of a research strategy that tests point-alternative hypotheses within a full-fledged research program. Because this strategy is free of various deficits that beset dominant strategies, our article demonstrates one way in which the confidence crisis may be overcome.

Before replication becomes mainstream, the potential for generating theoretical knowledge better be clear. Replicating statistically significant nonrandom data shows that an original study made a discovery; replicating a specified theoretical effect shows that an original study corroborated a theory. Yet only in the latter case is replication a necessary, sound, and worthwhile strategy.

Empirical tests of Schwartz’s theory of culture-level value priorities have predominantly been performed using an averaging approach–as values of the average individual in a culture. However, from a theory of measurement standpoint such an approach seems inadequate. We argue that the averaging approach is an insufficiently accurate methodology in capturing the compatibilities-incompatibilities between values of individuals within cultures. We propose an approach based on the distribution of values of individuals in a given culture–the distribution approach. Using data from two rounds (...) of the European Social Survey, we show how frequencies of specific individual value priorities in a culture can be used towards the description of culture-level value preferences. We recommend a re-conceptualization of Schwartz’s culture-level value theory to an orthogonal two-dimensional structure, namely as Preservation vs. Alteration and Dominance vs. Amenability, which we explain based on heterogeneity in socioecological indicators across countries. We conclude that societal challenges may influence the cultural value climate across countries. (shrink)

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© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)